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KMID : 0390320130230020155
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Chungbuk Medical Journal
2013 Volume.23 No. 2 p.155 ~ p.160
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Effect-site concentration of remifentanil for the relief of postoperative pain in the Intensive Care Unit patients
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Kang Hoon
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Abstract
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Purpose: This study was performed to determine the optimal doses of remifentanil (effect-site concentrations) required to prevent pain and other sufferings after abdominal general surgery in the ICU patients.
Materials and Methods: A total of 33 general abdominal surgical patients (aged 49-87 years and ASA II-III) requiring artificial ventilatory care in the ICU were provided with remifentanil through the target controlled infusion (TCI). Remifentanil concentrations were titrated up and down until the pain score became less than 3 (VAS; Visual Analogue Score < 3).
Results: The effect-site concentrations (ng/ml) of remifentanil required to adequately control postoperative pain in the ICU were 1.8+/-0.3, 1.7+/-0.3 and 1.4+/-0.5 for intubation with artificial ventilation, intubation with spontaneous ventilation and extubation, respectively
Conclusion: The three effect-site concentrations of remifentanil obtained from this clinical trial using the TCI technique can be a guideline in the administration of the same opioid to relieve patients’ discomforts in the ICU patients who underwent abdominal general surgery.
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KEYWORD
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Remifentanil, Effect-site concentration, Target Controlled Infusion
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